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Haneen M. Alsoltane ¹, Amel A. Altaee ¹

Affiliations
1 Babylon University/College of Science, IQ

Abstract

The present study was aimed to elucidate the effect of Nickel oxide nanoparticle (100mg /kg b.wt) on some parameters in pregnant Albino rats which including serum reproductive hormonal level, Leutinlizing Hormone (LH), Follicle stimulating Hormone ( FSH) and Testosterone (Test), and some Immunoglobulin levels (IgA, IgG, IgM) for different period of pregnancy ( 12 and 14 days). The hormonal results showed significant (P≤0.05) increased of treatment groups as compared with control groups. Immunological results showed significant decreases in treated groups as compared with control groups, It could be concluded that increasing concentrations of NIO- NPs and durations of exposure leads to negative effects on the pregnant albino rat.

Keywords

NIO, Nanoparticles, Albino Rats, Hormones, Immunoglobulin.

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Haneen M. Alsoltane ¹, Amel A. Altaee ¹

Affiliations
1 University of Babylon, College of Science, IQ

Abstract

The present study was aimed to elucidate the effect of Nickel oxide nanoparticles (100 mg / kg b.wt ) on some parameters in pregnant Albino rats,in both period of pregnancy (12 and14 days ). 30 albino rats were used; 20 female and the rest 10 were fertilized male rats which were used insemination only, the study including, maternal relative body weight, weight gain measurements and relative organ weights and histological study. Relative body weight of mothers showed decreases in both period of pregnancy. Body weight gain of the pregnant rat show decreases in 14 days of pregnancy in treated group as compared with control group while in 12 days of pregnancy showed increases in treated group as compared with control. Relative organ weight showed increases in (Lung, Uterus, kidney) in treated group and decreases in (Heart, Liver, Eye, Spleen, Brian) in (12) day of pregnancy. In ( 14 ) day of pregnancy showed decreases in (Heart, Liver, Eye, Brian , Kidney) and increases in (Lung, Spleen, Uterus) in treated group as compared with control group Histological study included some organ (liver, spleen, kidney, lung brain, eye and heart) for different period (12, 14) days of pregnancy.

Keywords

NIO, nanoparticles, albino rats, histology

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